Following a bad experience teaching at a public high school that resulted in a break from working, Haruaki Abe eagerly takes up a new job at Hyakki Academy. Despite his cowardice, the novice teacher is motivated to do better this time around. However, his mind quickly changes when he finds out that everyone at the school is actually a supernatural being known as a youkai, leaving him glaringly out of place as the only human around. Facing his class as its new homeroom teacher, Abe immediately becomes a target for the students' antics due to his quick-to-scare nature. Though as the man starts to learn more about the creatures, as well as himself, getting along with the unruly group might not be as hard as he originally thought as their school lives begin to get more vibrant.

To say that Mona Kawai is cute would be an understatement; she is breathtaking in every single way, and she knows it. At school, she is fawned over by boys and girls alike, and she graciously welcomes it all as a natural reaction to her irresistible charm. That is, until she comes across Medaka Kuroiwa, the boy who is seemingly immune to her overwhelming charisma. She goes out of her way to talk to him and even dials her cuteness up a notch, but no matter what she tries, Mona cannot wipe the scowl off Kuroiwa's face. Backed into a corner, Mona is forced to use the most devastating weapon in her arsenal: her physical allure. Such drastic measures would leave other boys foaming at their mouths, but Kuroiwa remains unfazed by her attempts. Little does Mona know that the only reason Kuroiwa just barely abstains from succumbing to her charms is because he is training to be a monk and thus trying his best not to be held down by worldly pleasures. As Mona goes all out to entice Kuroiwa, she fails to realize that his unintentional chivalry might just make her fall for him instead.

On a moonlit night, Akira Masaki finds herself in a magical world where wizards and humans coexist. Every year, they must face an enormous, deadly moon that attacks the planet. Their only hope lies with the Wizards of the Sage, appointed to fight the supernatural threat. But Akira soon discovers she wasn't summoned by chance—she was chosen to lead them in battle.

Coworkers Yui Mitsuya and Masugu Tateishi are the last people anyone would expect to get along—especially with their constant office quarrels. However, looks can be deceiving: they are actually dating! Afraid to lose the peace of their professional lives, Yui and Masugu play up their discord even more to ensure nobody discovers their secret. As awkward situations and close calls pile up, the risk of Yui and Masugu's coworkers catching on increases. Keeping up the pretense is not easy, but with each new day, their relationship only grows stronger.