Sixth grader Sana Kurata has a perfect life. Her mother is a (fairly) successful author, she has a young man employed to keep her happy and safe, and best of all, she is the star of the children's television show Kodomo no Omocha. There's just one thing bothering her, and that's Akito Hayama. Akito is a classmate of Sana's, and ever since he's started acting out in class, the rest of the boys have followed his example. Every day, the girls and the teacher wage a battle to keep the class under control and to get some actual learning done. That rotten Akito… Sana won't stand for this! The hyperactive Sana decides to dig deeper and find out what makes Akito tick, so class can go back to normal and the teacher can stop spending every day crying instead of teaching. But the more she learns about him, the more she realizes that there might be more to Akito than meets the eye.

On November 22, 2010, Japan was hit by missile strikes, a terrorist act that fortunately did not harm anyone, becoming known as "Careless Monday." Quickly forgotten, society goes on about their lives as normal. During her graduation trip to America three months later, friendly college student Saki Morimi's life is forever changed when she finds herself saved from unexpected trouble by Akira Takizawa. Takizawa is cheerful, but odd in many ways—he is stark naked and suffers from amnesia, believing himself to be a terrorist. In addition, he possesses a strange cell phone loaded with 8.2 billion yen in digital cash. Despite Takizawa's suspicious traits, Saki quickly befriends the enigmatic young man. However, unbeknownst to her, this is the beginning of a thrilling death game involving money, cell phones, and the salvation of the world. Higashi no Eden chronicles Saki's struggle to unravel the mysteries behind her savior, while Takizawa himself battles other individuals armed with similar cell phones and returning memories which reveal his possible connection to the event from months ago. [Written by MAL Rewrite]

After a brilliant victory over Saunders University High School, girls from Ooarai now have to face Italian-themed Anzio Girls High School in the second round of the 63rd National High School Sensha-Dou Tournament. The high-spirited girls from Anzio, led by the charismatic Chiyomi Anzai, advance toward the battle equipped with baffling tactics and a secret weapon. Ooarai will soon find out that what seemed to be a mere formality might take an unexpected and possibly disastrous turn. Whether they will win the match, or lose and doom their school to a closure, is still on a knife-edge.

The story follows a boy named Quon and others who suddenly wake up with supernatural powers.