It was a successful science experiment gone horribly wrong. When a team of scientists discovers the DNA of the ancient Pokémon Mew, they harnessed the potential within it in an attempt to create the ultimate living weapon. With advanced cloning techniques and resources provided to them by Team Rocket crime syndicate leader Giovanni, the scientists succeed in creating the powerful psychic Pokémon, Mewtwo.

Pokemon: Mewtwo no Gyakushuu reveals the terrifying power of Mewtwo as he learns that not only was he created to be an experiment, but also to be a tool for Giovanni’s sinister dealings. Breaking free of his control, Mewtwo creates his own island fortress and reconstructs the cloning technology that gave life to him.

Under the guise of being a master Pokémon trainer, Mewtwo lures the best trainers in the world to his base. Among these trainers are Ash Ketchum, his loyal Pokémon Pikachu, and their friends Brock and Misty. United together, human and Pokémon alike, they must not only discover the hidden secret of Mewtwo's plans, but stand against his terrifying might. If they fail, Mewtwo’s vengeance will not only lead to tyranny over all the Pokemon, but also the extinction of the human race.

In the witches' tradition, when a practitioner turns 15, they must become independent and leave their home to study witchcraft. Makoto Kowata is one such apprentice witch who leaves her parents' home in Yokohama in pursuit of knowledge and training. Along with her companion Chito, a black cat familiar, they embark on a journey to Aomori, a region favored by witches due to its abundance of nature and affinity with magic. They begin their new life by living with Makoto's second cousins, Kei Kuramoto and his little sister Chinatsu. While Makoto may seem to be attending high school like any other teenager, her whimsical and eccentric involvement with witchcraft sets her apart from others her age. From her encounter with an anthropomorphic dog fortune teller to the peculiar magic training she receives from her older sister Akane, Makoto's peaceful everyday life is filled with the idiosyncrasies of witchcraft that she shares with her friends and family. [Written by MAL Rewrite]

The year is 2148. Two years after the end of the original Fafner in the Azure TV series, Tatsumiya Island and its surviving residents have returned to some semblance of recovery. However, things have become desperate for our hero, Kazuki; nearly blind now, and partially crippled from his battles with the Festum two years earlier, he clings to the promise his fallen friend Soushi made to him to return to the island and set things right again. Kazuki's hopes flare when a lifeform is detected within an unmanned submarine that comes floating into Tatsumiya Bay one night, but the person aboard isn't Soushi; it is a mysterious "boy" named Misao Kurusu who may not be entirely human, and who claims to have been sent by Sōshi. With Misao's arrival, hostilities break out anew between the Human Army and the Festum, and the Fafner pilots are thrown into the most desperate battle of their lives - this time, with the fate of TWO races riding on their shoulders. 

(Source: Wikipedia)

Having escaped the many horrors of her village, Saya Kisaragi vows to hunt down the monster responsible and make him pay with his life. As she tears through flesh and bone for her vendetta, she encounters SIRRUT, a group of ingenious hackers, who enlist Saya to help them defeat a common enemy—someone she knows all too well. Unfortunately, the path she follows is paved with tragedy, as once again, Saya faces betrayal at the hands of those she has come to trust. With her back against the wall, the fearsome monster slayer must fight with all her strength and skill if she is to overcome this final mission and exact vengeance. [Written by MAL Rewrite]