Despite the Ends’ attack on Verlina being successfully repelled, the war has not yet ended. With the monster armies regrouping, the Black King tightens his grasp on the already conquered territory. New conflicts erupt all across Orte, as its remaining forces struggle to retain control over long-oppressed demi-human races. While Ends grow more potent each day, Toyohisa Shimazu remains unconscious after heavy injuries suffered during the Battle of Verlina. Facing enemies on every side, humanity’s fate is still on a knife's edge.

D.S.O. agent Leon S. Kennedy is on a mission to rescue Dr. Antonio Taylor from kidnappers, when a mysterious woman thwarts his pursuit. Meanwhile, B.S.A.A. agent Chris Redfield is investigating a zombie outbreak in San Francisco, where the cause of the infection cannot be identified. The only thing the victims have in common is that they all visited Alcatraz Island recently. Following that clue, Chris and his team head to the island, where a new horror awaits them.

Iria is the story of a girl and the Alien being she loves to hate. The series begins with her brother, Gren, taking a job. He is a bounty hunter, and one well known for his incredible skill. Iria, being a skilled apprentice bounty hunter herself, tags along. What is the job, one might ask. It is to find out what has happened to the crew and cargo of a Space Station. Needless to say, nothing is as it seems, and the war between Iria and Zeiram begins in earnest.

The entire countryside comes to a halt midday to witness a rare solar eclipse that is rumored to allow the average person to see Mushi. Unable to avert their gaze, the air is full of awe and wonder—but those who know the Mushi are preparing for the eclipse's aftermath. Based on a prediction from Tanyuu Karibusa, the cursed recorder, Mushishi Ginko finds himself in a very unlucky farming village. Immediately following the solar eclipse, a strange black cloud begins to gather in the sky and blocks the sun once more. Suspecting it to be the work of a Mushi known as Hihami, Ginko seeks to liberate the village from perpetual darkness. However, it seems that not all of the villagers are eager to return to the light.