Friends will only let you down—that is the sad truth Mei Tachibana lives with, ever since she was wrongfully blamed for the death of a class pet by her so-called friends in grade school. Since then, she stays away from people in order to avoid ever being hurt again. However, Mei's life begins to change drastically when a misunderstanding in high school causes her to encounter popular student Yamato Kurosawa. Yamato finds her intriguing and insists on being her friend, even though Mei wants nothing to do with him. But when a dangerous situation ends with Yamato kissing Mei to save her from the unwanted attention of a stalker, Mei begins to develop feelings for him. On the heels of her discovery that their feelings are mutual, they start dating and she gains not only a boyfriend, but friends as well. Mei, however, finds it very hard to adapt to this new lifestyle, especially in expressing her true feelings towards Yamato. Throughout misunderstandings of their new relationship, each other, and the attentions of other girls, Mei and Yamato slowly grow closer and learn the true meaning of those three little words: "I love you."

Throughout Shibuya, a series of murders dubbed the "New Generation Madness" gained widespread attention As these crimes gained infamy, they became a hot topic of discussion among the people of the area. Nonetheless, these "New Gen" murders do not capture the interest of Takumi Nishijou, a high school otaku who frequently experiences delusions and feels that he is constantly being watched. Having no concern for the real world, Takumi spends his time playing online games and watching anime. However, his ordinary life is disrupted when he receives a horrifying image of a man staked to a wall from a user named Shogun. After calming himself at an internet cafe, Takumi sees the exact same murder scene as the image portrayed happen right before his eyes, along with a pink-haired girl covered in blood calling out his name. Conflicted with the nature of reality, Takumi finds it difficult to judge where to place his trust as he gets caught up in the "New Gen" murders, believing that the murderer is out to get him.

The anime's story will start where the third season left off, at the competition for who will open the Triple S international sporting event. Raging Entertainment's HE★VENS idol group had hijacked the competition between QUARTET NIGHT and ST☆RISH, causing chaos. However, after the QUARTET NIGHT members suggest a certain idea, the three groups aim toward a new stage, with HE★VENS swearing to get their revenge on the other two groups.

Ichiko Sakura lives life on easy mode. Blessed with good fortune, she has everything she has ever wanted, including beauty, intelligence, and wealth. Momiji Binboda is a goddess of poverty. In stark contrast to Ichiko, she is cursed with misfortune, such as a perpetual cast on her arm, a flat chest, and a box under a bridge for a home. Their lives collide when Momiji lives up to her title and delivers some unfortunate news to Ichiko: her large amount of luck is due to her subconsciously draining the luck from those around her! Momiji has been tasked with stealing back Ichiko's fortune before she leaves everyone without enough luck to even survive. But Ichiko, with the help of the wandering monk Bobby Statice, manages to fight off the poverty goddess. This defeat forces the goddess to enlist reinforcements in the form of Kumagai, her teddy bear familiar, and the masochistic dog god, Momoo Inugami. Insanity ensues as Ichiko's quiet life is replaced with daily battles for her fortune. To survive the chaos, Ichiko will need all the luck she can get in Binbougami ga!! [Written by MAL Rewrite]