The game is set in the continent of Babel, where the Tower of Babel looms large over seven nations. After the invention of alchemy led to its use as a tool of war that brought humanity to the brink of extinction, the seven nations struck an uneasy peace that led to a prohibition on alchemy for hundreds of years since. In the Continental Year 911, the nation of Lustrice broke the pact by assembling an army bolstered by alchemy, with ambitions of conquest over the continent. Led by Envylia, the six nations allied and struck down the rogue nation, casting alchemy once again to darkness. But 20 years after the war, alchemy once again begins to cause chaos in the land. 

(Source: ANN)

The plot of this OVA is a rough adaptation of the first four chapters of the Guyver manga. It covers the same basic elements of these chapters; Genesis of the guyver, Fight with Vamore, Fight with Guyver 2 and the introduction of Guyver 3. Main differences are the exclusion of Tetsuro and his replacement by Mizuki, The replacement of Lisker with a female Agent "Valcuria", and thus a female Guyver 2. There is also a look at Sho's psychology of how he deals with his situation including a very harsh moment where his friends are assassinated in cold blood. One night, high school student Sho Fukamachi discovers a mysterious metal object. Then in a blinding flash of light, Sho finds that he has accidentally fused with the Guyver, a mecha of mysterious alien design. Now, to save his girlfriend, Mizuki Segawa, along with the entire world, Sho must become the Guyver to fight the Chronos Corporation and their biocreatures, called Zoanoids, who are hell-bent on world domination.

Daigo Asahina is Medaka Gumi #2's/Me Gumi's new rookie firefighter, and already he's done crazy things, like throwing people off of a rooftop to save them from an explosion. He had good intentions, but his deeds are starting to hurt the company's reputation. At Sengoku City's Concert Hall, a fire breaks, and the some Emergency Rescue Squad needs rescuing. Daigo will do all he can to keep his promise: Not to let anyone die on the job.

The fairy tale follows a young man named Budori Gusuko in the Tohoku forests of northeastern Japan in the 1920s. After an onslaught of droughts and natural disasters, Budori is forced to leave his home and search for a better life elsewhere. Budori joins a group of scientists at the Ihatov Volcano Department, which deals with the same natural disasters that drove Budori from his home.