Fumiya Tomozaki is Japan's best player in the online game Attack Families, commonly known as "Tackfam." Despite holding such a revered title, a lack of social skills and amiability causes him to fall short in his everyday high school life. Failing to have any friends, he blames the convoluted mechanics and unfair rules of life, forcing him to give up and proclaim himself a bottom-tier character in this "game." After a fateful meeting with another top-tier Tackfam player, Fumiya is shocked to discover the player's true identity—Aoi Hinami, a popular, smart, and sociable classmate who is the complete opposite of himself. Aoi, surprised at how inept Fumiya is at everything besides Tackfam, decides to assist him in succeeding in what she calls the greatest game of them all. Through the gruesome ordeals of social interactions and relationships, Fumiya begins to advance tiers in the glorious game of life. [Written by MAL Rewrite]

After harboring an unrequited love for years, Naoya Mukai finally gets to date his childhood friend, Saki Saki. However, just as he tries to commit himself to this relationship, he receives an abrupt confession from Nagisa Minase. At first, Naoya tries to reject her but is soon overcome by feelings of not wanting to hurt Nagisa. Trying to avoid betraying his girlfriend's trust in him, Naoya thinks up a "solution" to make both girls happy—two-timing. Naturally, Saki rebuffs this idea, but through Naoya's and Nagisa's persistence, she reluctantly submits. With this, a three-way affair begins between Naoya, his girlfriend, and his "other" girlfriend, as they develop a relationship that deviates from the social norm.

The hero king Inglis—who dedicated his entire life to building his country—is now approaching death. To award him for his honorable achievements, the goddess Alistia appears and grants him one wish. Having never been able to master the blade, Inglis asks to be reincarnated in order to do so. In a blink of an eye, Inglis finds himself born in the far future as a daughter of the Eucus noble family. Six years later, Inglis is discovered to be Runeless—incapable of utilizing the runes that enable the use of magic in this era. She is therefore ineligible to become a knight. However, this fits in well with Inglis' plan: she instead decides to become the squire for her cousin, Rafinha Bilford, allowing Inglis to focus on pushing her limits. For Inglis, the challenges this familiar yet different world has to offer are instead opportunities for her to hone her skills—and possibly become an extraordinary squire in the process.

World-class medical researcher Kanji Yakutani lost his little sister to a tumor years ago due to ineffective treatment. To honor her legacy, he has dedicated his research to developing new medications for such conditions. But as fate would have it, he overworks himself and passes away at the age of 31, only to be given a second chance at life in another world. When he wakes up, Kanji finds himself in the body of a 10-year-old boy named Falma de Médicis, the son of an esteemed family of medical practitioners in the Sain Fleuve Empire. Bearing the mark of a deity's divine blessing, Falma is capable of performing a unique divine art, allowing him to create and reduce any substance with the knowledge of its chemical properties. After reading through some pharmacology books, Falma realizes that this world is operating on similar medical practices as in ancient times. He also learns that medicine is an exclusive privilege to the nobility, depriving commoners of proper medical care. Using the knowledge from his past life and the divine abilities granted to him, Falma resolves to make medicine available to those who need it—irrespective of class.