In the distant future, because of an interplanetary war that had continued on for centuries, civilizations were ruined. Human beings have lost everything, and only 1/5th of the population survived. A strange breed of humans, ''The Third'' is said to have appeared just after the war. They possess a third eye, as their name suggests, that appear as oval-shaped red pupils called "space eyes'' over their conventional two eyes. Using them, they can control computer systems and so on, and as such, rule the world by their superior power over technology. In this world, there is a young woman named Honoka; she is a "jack-of-all-trades" sellsword, and she accepts any job except murder. One day, she happens to find and rescue a young man named Ikus in the desert. Entering his world, and accepting a job from him, the adventure begins for Honoka and Ikus.

When 16-year-old Nanako Misonoo enters the prestigious all-girls Seiran Academy, she believes a bright future awaits her. Instead, the unlucky girl finds herself dragged into a web of deceit, misery, and jealousy. On top of that, she is chosen as the newest inductee of the Sorority, an elite group whose members are the envy of the entire school. Having none of the grace, wealth, or talent of the other members, Nanako quickly draws the ire of her jealous classmates—especially the fierce Aya Misaki. To cope with her increasingly difficult school life, Nanako recalls her days through letters to her former teacher, Takehiko Henmi, whom she affectionately calls "onii-sama" (big brother). She also finds comfort with her four closest friends: her childhood friend Tomoko Arikura, the sociable but erratic Mariko Shinobu, the troubled musician Rei Asaka, and the athletic tomboy Kaoru Orihara. An impassioned drama about the hardships of bullying, Oniisama e... chronicles a young girl's harsh life at her new school, as she endures cruel rumours, heartless classmates, and countless social trials. [Written by MAL Rewrite]

Kyuu is your average boy with a knack for logic and reasoning. Desiring to become a detective, he finds out about the existence of the Dan Detective School (DDS); a famed school where students are allowed to bear arms. Together with Megu, a girl with photographic memory, the martial arts master Kinta, the genius programmer Kazuma and the mysterious Ryuu, Kyuu tackles many well planned out crimes, always seeking the truth.

The comedy anime centers on five girls and one cat all living as housemates in Nakano, Tokyo: the three Himote sisters (Tokiyo, Kinami, and Kokoro) whose family manages the "Himote House," Kokoro's classmates Tae and Minamo, and the cat Enishi. The girls live their daily lives trying to figure out ways to be popular, and they (and the cat) all possess a mysterious secret power... (Source: ANN)