It is said that 70% of the human brain capacity is unused. If humans possess incredible power, it is strongly believed to be lying dormant within this region. This unused 70% brain capacity is known as "Night Head". The famous work 'NIGHT HEAD' is going to break the silence. They were abandoned by their parents because of the psychic power they possessed. They are the Kirihara brothers, who lived in a laboratory within a barrier-protected forest. They have escaped from the laboratory, and a new wave of 'Revolution' is about to arise. A new "Night Head" is about to be awakened.

Jubei Kibagami wanders feudal Japan as an itinerant swordsman-for-hire. After a past betrayal left him masterless, he has no more patience for warring political factions and their schemes. Unfortunately, both past and political intrigue collide when he meets and saves a female ninja named Kagero from a man with the ability to make his body as hard as stone. The sole survivor of a ninja clan, Kagero continues her team's last mission: investigate a mysterious plague that wiped out an entire village. Jubei wants nothing to do with this, but the stone-like man's allies, a group of ninja with supernatural powers known as the Devils of Kimon, make that option difficult. To make matters worse, a government spy poisons Jubei, promising him an antidote if he can unravel the true intentions of the Devils of Kimon and their connection to the plague. The trail leads to shadow leaders, a plot to overthrow the government, and a man that Jubei thought he would never see again.

Fourteen years after defeating the immortal warrior Himuro Genma and thwarting the Shogun of the Dark's evil plans, Kibagami Jubei continues to roam all over Japan as a masterless swordsman. During his journey, he meets Shigure, a priestess who has never seen the world outside her village. But when a group of demons destroys the village and kills everyone, Jubei becomes a prime target after acquiring the Dragon Jewel—a stone with an unknown origin. Meanwhile, Shigure—along with the monk Dakuan and a young thief named Tsubute—travels to the village of Yagyu. And with two demon clans now hunting down Shigure, Dakuan must once again acquire the services of Jubei to protect the Priestess of Light.

Himeji Wakaba is a 5th year elementary school student, and she has the ability to see things that others can't. They are mostly frightening evil spirits, and they tend to do bad things to people who are close to her. As a result, Wakaba has no friends and rarely smiles. On a couple of occasions, she brings home stray animals, but her parents won't let her keep them. However, they're worried about their sad, creepy daughter, so one day they decide that whatever Wakaba brings home next, they'll let her keep. The next thing she brings home is a pink monster called "Pupipo", but her parents stand by their decision and let her keep it. No one is quite sure what Pupipo is, but it protects Wakaba from the other things she sees. Pupipo also helps Wakaba make friends with an occult-obsessed transfer student and solve problems with bullying. Wakaba's life is a much better place with her pet pink monster!