A mysterious gem called the "Skull Stone" is said to be able to reveal the location of the largest vein of gold in the world. This legend has entranced many people who wanted to get their hands on fame, power and wealth, including the trio of villains in this show: the "Dorombo Gang." However, their hunt for the Skull Stone is not as easy as they imagined, mainly due to the faulty information they receive from their leader, and most of all, by a justical duo of pursuers called the "Yatterman"!

Picks up after the events of Transformers 2010. Ultra Magnus goes on a solo mission through various Decepticon strongholds to find out exactly what happened to Optimus.

Short episodes streamed on the anime's official site after every episode, giving background information about the show.

Headmasters starts with Galvatron leading a new batch of Destrons to wage war on Cybertron, the Destron Headmasters. The Cybertrons are rescued by the arrival of the Cybertron Headmasters, led by Fortress (Cerebros, the head of Fortress Maximus). It is revealed that Fortress Maximus left Cybertron millions of years ago in search of energy, and have finally managed to come home. He explains that the Headmasters are from a planet called Master; the human-sized robots who live there built themselves Transformers-sized bodies. They can then transform themselves into the heads of the robots, and have now joined the Cybertron-Destron war.