The entire countryside comes to a halt midday to witness a rare solar eclipse that is rumored to allow the average person to see Mushi. Unable to avert their gaze, the air is full of awe and wonder—but those who know the Mushi are preparing for the eclipse's aftermath. Based on a prediction from Tanyuu Karibusa, the cursed recorder, Mushishi Ginko finds himself in a very unlucky farming village. Immediately following the solar eclipse, a strange black cloud begins to gather in the sky and blocks the sun once more. Suspecting it to be the work of a Mushi known as Hihami, Ginko seeks to liberate the village from perpetual darkness. However, it seems that not all of the villagers are eager to return to the light.

With reports of monsters terrorizing the reactor at Mount Nibel, the Shinra Electric Power Company dispatches their elite fighting force SOLDIER to investigate. Accompanied by fellow SOLDIER First Class Zack Fair and a small contingent of company guards, the war hero Sephiroth is to assess the condition of the Mako reactor at the behest of the company. In Nibelheim, the village that the reactor powers, Sephiroth discovers the source of the monsters and the origins of Shinra's legendary Jenova Project. Running through the woods months later, Zack is no longer the hero he once dreamt of becoming. He flees from the General Affairs Department of the Shinra Electric Power Company, better known as the Turks, who desperately seek to bury the evidence living within the two.

"U" is a popular social media platform where people can create a virtual persona and start a new life. Among its five billion users, one newcomer is quickly gaining attention: Belle, a beautiful singer whose alluring melodies slowly capture the hearts of the masses. But in this space where everyone hides behind an avatar, curiosity arises over who the mysterious girl truly is. Suzu Naito—a shy girl from the countryside—can no longer sing following past trauma, all her efforts resulting in breakdowns and illness. However, when Suzu joins U, she is once again able to project her voice. Under the alias "Belle," her vocals soon go viral, receiving both love and hatred. Meanwhile, rumors spread of a chaotic beast within U, known only as "The Dragon." After a chance meeting during her concert, Belle finds he is not as evil as the stories suggest. Now, both online and in the real world, Suzu has to face the struggles of identity, fame, and opening one's heart.