By the mid-21st century, Tokyo's criminal underworld is ruled by Demon Lords—crime bosses who have undergone ether enhancement surgery, granting them terrifying superpowers. The only ones who can take them down are Heroes, bounty hunters who boost their own ether powers using the drug E3 (E-Three). With legalized killing as part of the job, being a Hero is less about justice and more about survival. Yashiro, known as the Reaper, is one such Hero—an independent enforcer who works alone. That is, until Jougamine, a high school girl and self-proclaimed "apprentice," forces her way into his life. Reluctantly taking her under his wing, Yashiro soon finds himself caught in a whirlwind of deadly conflicts.

Dorohedoro: Ma no Omake further explores the world of sorcerers and the Hole, honing in on what the characters do in their spare time when they are not seeking out their enemies. Kamen Kakusa Fujita attends a mask conjuring ritual in hopes of a Devil bestowing him with an appropriate mask, like the ones his colleagues Noi and Shin possess. Hopefully his offering entices the mask-maker! Tenpo For You Nikaidou, lacking money and forced to sell gyoza on the streets of the Hole, stumbles upon a quaint shop selling tea and sweets. Its owner is the gentle and hospitable Syueron, but it seems the denizens of the Hole bear a grudge against him. Shitappa Seishun Graffiti Intrigued by the photographs hanging around the mansion, Ebisu approaches En hoping for a portrait of her own. However, she is disappointed to find that only members of the En Family can have their pictures taken. Anata no Shiranai Gyoza no Kai The Gyoza Fairy keeps the Hungry Bug in pristine condition, but his primary responsibility is ensuring the gyoza tastes good. So he becomes rather agitated when Nikaidou's customers do not properly enjoy their meals. Odoru Ma no Utage En is enthusiastic about his masquerade ball and is adamant on his family's participation. Per tradition, attendees must choose a partner and dance to appease the Devils. To their horror, they discover that failing to do so may incur nasty consequences! Yokaze ni Fukarete Ooba Kinenbi Nikaidou gives detailed instructions on preparing oba gyoza and Kaiman is eager to help!

Kaya-chan is infamous at kindergarten for being a troublemaker. But Ms. Chie, who's been assigned to look after her, soon discovers Kaya's hidden abilities. Get ready for the ultimate horror-action adventure set in kindergarten!

Second season of . Yu Wanyin is teleported into a novel about palace struggles. The female protagonist of the novel is also teleported into it. To reverse her fate as a villain, Yu Wanyin chooses to join forces with a tyrant, who also turns out to be a modern man teleported in. Yu Wanyin hopes for the three modern people to put aside the palace struggles and just play cards and eat hotpot together peacefully. However, the female protagonist believes she is the chosen one, and still chooses to go against Yu Wanyin and the male protagonist King Duan's team. Thus, Yu Wanyin has to carry out a series of actions in order to survive and help Xia dynasty prevent the drought crisis...