A year after the events of Fushigi Yuugi, Tamahome is pulled back into the book and is sent on a complicated ride through illusion, confusion, and betrayal. Meanwhile, Yui is acting oddly and Miaka is heartbroken over the loss of Tamahome, while Keisuke and Tetsuya try to discover what is going on with the book. (Source: ANN)

Kujo Jotaro is a normal, popular Japanese high-schooler, until he thinks that he is possessed by a spirit, and locks himself in prison. After seeing his grandfather, Joseph Joestar, and fighting Joseph's friend Muhammad Abdul, Jotaro learns that the "Spirit" is actually Star Platinum, his Stand, or fighting energy given a semi-solid form. Later, his mother gains a Stand, and becomes sick. Jotaro learns that it is because the vampire Dio Brando has been revived 100 years after his defeat to Jonathan Joestar, Jotaro's great-great-grandfather. Jotaro decides to join Joseph and Abdul in a trip to Egypt to defeat Dio once and for all.

The once famous and well respected scientist Zorndyke has bred a new genre of living being, one that thrives on the oceans and lives to destroy humans. Zorndyke believes it is time that the humans were relieved of their rule of the earth. It is up to Blue Submarine No. 6 and the rest of the Blue fleet to put an end to Zorndyke's madness and creations. (Source: ANN)

Taka (technically Tamahome) and Miaka are now happily married and only six months before their new family would be born, but an obsessed girl named Mayo would do anything to make Taka hers. She enters the world of the Four Gods, determined to win Taka's heart and be the new priestess.