When his wife is burned at the stake after being falsely accused of witchcraft, the vampire Count Vlad Dracula Țepeș declares all the people of Wallachia will pay with their lives. He summons an army of demons which overruns the country, causing the people to live lives of fear and distrust. To combat this, the outcast monster hunter Trevor Belmont takes up arms against Dracula's forces, aided by the magician Sypha Belnades and Dracula's dhampir son Alucard.

In the coastal city of Naples, corruption is teeming—the police blatantly conspire with outlaws, drugs run rampant around the youth, and the mafia governs the streets with an iron fist. However, various fateful encounters will soon occur. Enter Giorno Giovanna, a 15-year-old boy with an eccentric connection to the Joestar family, who makes a living out of part-time jobs and pickpocketing. Furthermore, he is gifted with the unexplained Stand ability to give and create life—growing plants from the ground and turning inanimate objects into live animals, an ability he has dubbed "Gold Experience." Fascinated by the might of local gangsters, Giorno has dreamed of rising up in their ranks and becoming a "Gang-Star," a feat made possible by his encounter with Bruno Buccellati, a member of the Passione gang with his own sense of justice. JoJo no Kimyou na Bouken: Ougon no Kaze follows the endeavors of Giorno after joining Bruno's team while working under Passione, fending off other gangsters and secretly plotting to overthrow their mysterious boss.

The year is 1999. Morioh, a normally quiet and peaceful town, has recently become a hotbed of strange activity. Joutarou Kuujou, now a marine biologist, heads to the mysterious town to meet Jousuke Higashikata. While the two may seem like strangers at first, Jousuke is actually the illegitimate child of Joutarou's grandfather, Joseph Joestar. When they meet, Joutarou realizes that he may have more in common with Jousuke than just a blood relation. Along with the mild-mannered Kouichi Hirose and the boisterous Okuyasu Nijimura, the group dedicates themselves to investigating recent disappearances and other suspicious occurrences within Morioh. Aided by the power of Stands, the four men will encounter danger at every street corner, as it is up to them to unravel the town's secrets, before another occurs.

Joutarou Kuujou and his allies have finally made it to Egypt, where the immortal Dio awaits. Upon their arrival, the group gains a new comrade: Iggy, a mutt who wields the Stand "The Fool." It's not all good news however, as standing in their path is a new group of Stand users who serve Dio, each with a Stand representative of an ancient Egyptian god. As their final battle approaches, it is a race against time to break Joutarou's mother free from her curse and end Dio's reign of terror over the Joestar family once and for all.